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- Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension, 1995. 26:485-490.
- Low molecular weight heparins : a guide to their optimum use in pregnancy. Drugs, 2002. 62:463-477.
- Influence of L-NAME, acetylcholine and adenosine on mean blood pressure, pulse pressure and pulse pressure amplification in rats. Journal of Cardiovascular Pharmacology, 2003. 41:210-8.
- Heart rate and pulse pressure amplification in hypertensive subjects. American Journal of Hypertension 2003. May;16(5):363-70.
- Gender influence on the relation between heart rate and aortic stiffness. Journal of Hypertension 2003. 21:555-562
- Pulse pressure and arterial stiffness in rats: comparison with humans. American Journal of Physiology - Heart and Circulatory Physiology, 2003. 285(4):H1363-9.

Albaladejo P, Laurent P, Pannier B, Achimatos A, Safar M.E, Benetos A. Gender influence on the relation between heart rate and aortic stiffness. Journal of Hypertension 2003. 21:555-562

Abstract :

Heart rate and aortic pulse wave velocity (PWV) are both cardiovascular risk factors. The aim of this study was to evaluate the influence of sex on the heart rate-PWV relationship in two populations of normotensive and hypertensive men and women.

PATIENTS AND METHODS : In a first study, steady-state data describing the heart rate-PWV relationship were determined in 558 normotensive men, 308 normotensive women, 323 hypertensive men and 93 hypertensive women. In a second study, the changes in blood pressure and PWV under atrial pacing at 60, 80 and 100 beats/min were investigated in 15 men and 15 women who were either normotensive or hypertensive.

RESULTS : In women in study 1, 26.8% of PWV variance in normotensive patients and 15.4% of PWV variance in hypertensive patients was explained by a multiple regression including only age and systolic blood pressure as covariates. In men in study 1, 27% of PWV variance in normotensive patients and 28.5% of PWV variance in hypertensive patients was explained by a multiple regression including age, systolic blood pressure, weight, and also heart rate, as covariates. In study 2, atrial pacing in the overall population tended to decrease mean blood pressure (P = 0.05) and increase pulse pressure (P = 0.003), with no substantial change in PWV. However, when heart rate increased, PWV tended to decrease in women and to increase in men (interaction: P = 0.07).

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